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How do you open Cohen's Muse Box?

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When you finish the masterpiece he will reward you with the new tonic. After that he will continue to admire his masterpiece. When you hit/shoot him a battle against him will ensue. He has powers like that of a fire base Houdini splicer. (Just follow the spotlight to see where he will appear) after killing him search his body. You will find the key to the box. Also take a photo of him to acquire a new achievement "Irony"

You can find the key to this box on Cohen's corpse after you kill him. The box contains 100 dollars, 8 Incendiary Bolts, and 3 Spider Splicer Organs.

Under another users playthrough, they instead recieved 69 dollars,but still got the 8 Incendiary Bolts and 3 Spider Slicer Organs. The amount of money may have different factors to change it, such as possibly the difficulty.

If you kill him in his apartment (in Point Prometheus) and take a picture of him you can also get two different trophies too!

You need to kill Cohen. Whether you do this in Fort Frolic or Point Prometheus in his apartment is up to you, but to get into his apartment, and get "Found Cohen's Room" - A secret achievement/trophy, you will need to leave him at Fort Frolic. There is also a secret achievement/trophy called "Irony", in which you must take a photo of Cohen's corpse.

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