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Welcome to BioShock Answers. What would you like to know?

That depends on what you mean by "weakness". Big Daddies aren't like traditional boss battles where you would need to use the right elemental attack or hit the right soft-spot; each type of Big Daddy (Rosies and Bouncers) require a different strategy to defeat. In BioShock the combination of weapons, plasmids and taking advantage of the environment allow endless possibilities for dealing with an enemy. I suggest you check out the strategy sections of the Rosie and Bouncer pages at the BioShock Wiki for more info.

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