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That depends on what you mean by "weakness". Big Daddies aren't like traditional boss battles where you would need to use the right elemental attack or hit the right soft-spot; each type of Big Daddy (Rosies and Bouncers) require a different strategy to defeat. In BioShock the combination of weapons, plasmids and taking advantage of the environment allow endless possibilities for dealing with an enemy. I suggest you check out the strategy sections of the Rosie and Bouncer pages at the BioShock Wiki for more info.

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